Aβ ELISA kit reference List

292-62301 Human β Amyloid(1-40) ELISA Kit Wako

1. Zhang, C., et al.: J. Biol. Chem., 285, 37, 28472(2010).

Curcumin decreases amyloid-beta peptide levels by attenuating the maturation of amyloid-beta precursor protein.

https://www.ncbi.nlm.nih.gov/pubmed/20622013

2. Serrano-Pozo A., et al.: Alzheimer Dis. Assoc. Disord., 3, 220(2010).

Effects of Simvastatin on Cholesterol Metabolism and Alzheimer Disease Biomarkers https://www.ncbi.nlm.nih.gov/pubmed/20473136

3. Zhang, C., et al.: J. Alzheimers Dis., 22, 2, 683(2010).

Amyloid-β production via cleavage of amyloid-β protein precursor is modulated by cell density. https://www.ncbi.nlm.nih.gov/pubmed/20847415

4. Head, E., et al.: J. Alzheimers Dis., 23, 3, 399(2011).

Plasma amyloid-β as a function of age, level of intellectual disability, and presence of dementia in Down syndrome.

https://www.ncbi.nlm.nih.gov/pubmed/21116050

5. Koppel, J., et al.: Mol. Med., 20, 29(2014).

CB2 Receptor Deficiency Increases Amyloid Pathology and Alters Tau Processing in a Transgenic Mouse Model of Alzheimer’s Disease

https://www.ncbi.nlm.nih.gov/pubmed/24722782

6. Xie, Z., et al.: Ann. Clin. Transl. Neurol., 1, 5, 319(2014).

Preoperative cerebrospinal fluid β-Amyloid/Tau ratio and postoperative delirium. https://www.ncbi.nlm.nih.gov/pubmed/24860840

7. Gonzales C., et al.: Pharmacol. Biochem. Behav., 126, 28(2014).

Alternative method of oral administration by peanut butter pellet formulation results in target engagement of BACE1 and attenuation of gavage-induced stress responses in mice https://www.ncbi.nlm.nih.gov/pubmed/25242810

8. Waragai M., et al.: J. Alzheimers Dis., 41, 4, 1207(2014).

Utility of SPM8 plus DARTEL (VSRAD) combined with magnetic resonance spectroscopy as adjunct techniques for screening and predicting dementia due to Alzheimer's disease in clinical practice

https://www.ncbi.nlm.nih.gov/pubmed/24787913

9. Oka, S. et al.: Sci. Rep., 6, 37889(2016).

Human mitochondrial transcriptional factor A breaks the mitochondria-mediated vicious cycle in Alzheimer's disease.

https://www.ncbi.nlm.nih.gov/pubmed/27897204

10. Tateno, A., et al.: Alzheimers Dement. (Amst)., 9, 51(2017).

Effect of apolipoprotein E phenotype on the association of plasma amyloid β and amyloid positron emission tomography imaging in Japan. https://www.ncbi.nlm.nih.gov/pubmed/28975146

11. Bourdenx, M., et al.: Sci. Rep., 7, 45831(2017).

Lack of spontaneous age-related brain pathology in Octodon degus: a reappraisal of the model. https://www.ncbi.nlm.nih.gov/pubmed/28374864

12 Waragai, M., et al.: J. Alzheimers Dis., 60, 4, 1411(2017).

Decreased N-Acetyl Aspartate/Myo-Inositol Ratio in the Posterior Cingulate Cortex Shown by Magnetic Resonance Spectroscopy May Be One of the Risk Markers of Preclinical Alzheimer's Disease: A 7-Year Follow-Up Study.

 https://www.ncbi.nlm.nih.gov/pubmed/28968236

13. Brubaker, W. D., et al.: Alzheimers Dement., 12, 1397(2017).

Peripheral complement interactions with amyloid β peptide: Erythrocyte clearance mechanisms https://www.ncbi.nlm.nih.gov/pubmed/28475854

14. Kanatsu, K., et al.: J. Neurochem., 147, 1, 110(2018).

Retrograde transport of γ-secretase from endosomes to the trans-Golgi network regulates Aβ42 production.

https://www.ncbi.nlm.nih.gov/pubmed/29851073

15. Ohshima, Y., et al.: Heliyon, 4, 1, e00511(2018).

Mutations in the β-amyloid precursor protein in familial Alzheimer's disease increase Aβ oligomer production in cellular models

https://www.ncbi.nlm.nih.gov/pubmed/29560429

16. Ohshima, Y., et al.: J. Toxicol. Sci., 43, 4, 257(2018).

Nicotine and methyl vinyl ketone, major components of cigarette smoke extracts, increase protective amyloid-β peptides in cells harboring amyloid-β precursor protein. https://www.ncbi.nlm.nih.gov/pubmed/29618714

17. Kara, E., et al.: J. Biol. Chem., 293, 34, 13247(2018).

A flow cytometry–based in vitro assay reveals that formation of apolipoprotein E (ApoE)–amyloid beta complexes depends on ApoE isoform and cell type https://www.ncbi.nlm.nih.gov/pubmed/29950521

18. Kusakari, S., et al.: J. Neurochem., 144, 2, 218(2018).

Calmodulin-like skin protein protects against spatial learning impairment in a mouse model of Alzheimer disease.

https://www.ncbi.nlm.nih.gov/pubmed/29164613

19. Meyer, K., et al.: Cell Rep. 26, 5, 1112(2019).

REST and Neural Gene Network Dysregulation in iPSC Models of Alzheimer’s Disease https://www.ncbi.nlm.nih.gov/pubmed/30699343

298-64601 Human βAmyloid(1-40)ELISA Kit Wako Ⅱ

1. Chiba, T., et al.: Mol. Psychiatry, 2, 206(2009).

Amyloid-β causes memory impairment by disturbing the JAK2/STAT3 axis in hippocampal neurons

https://www.ncbi.nlm.nih.gov/pubmed/18813209

2. Ohta, K., et al.: Autophagy, 3, 345(2010).

Autophagy impairment stimulates PS1 expression and γ-secretase activity https://www.ncbi.nlm.nih.gov/pubmed/20168091

3. Umeda, T., et al.: Life Sci., 91, 23, 1169(2012).

Hypercholesterolemia accelerates intraneuronal accumulation of Aβ oligomers resulting in memory impairment in Alzheimer's disease model mice https://www.ncbi.nlm.nih.gov/pubmed/22273754

4. Richens, J. L., et al.: Int. J. Mol. Epidemiol. Genet., 5, 2, 53(2014).

Practical detection of a definitive biomarker panel for Alzheimer's disease; comparisons between matched plasma and cerebrospinal fluid https://www.ncbi.nlm.nih.gov/pubmed/24959311

5. Katsuda, T., et al.: Methods Mol. Biol., 1212, 171(2015).

Potential Application of Extracellular Vesicles of Human Adipose Tissue-Derived Mesenchymal Stem Cells in Alzheimer’s Disease Therapeutics https://www.ncbi.nlm.nih.gov/pubmed/25085563

6. Yokoyama, H., et al.: BMC Geriatr., 15, 60(2015).

The effect of cognitive-motor dual-task training on cognitive function and plasma amyloid β peptide 42/40 ratio in healthy elderly persons: a randomized controlled trial https://www.ncbi.nlm.nih.gov/pubmed/26018225

7. Schütt, T., et al.: J. Vet. Intern. Med., 29, 6, 1569(2015).

Cognitive function, progression of age‐related behavioral changes, biomarkers, and survival in dogs more than 8 years old

https://www.ncbi.nlm.nih.gov/pubmed/26463980

8. Schütt, T., et al.: J. Alzheimers Dis., 52, 2, 433(2016).

Dogs with Cognitive Dysfunction as a Spontaneous Model for Early Alzheimer's Disease: A Translational Study of Neuropathological and Inflammatory Markers. https://www.ncbi.nlm.nih.gov/pubmed/27003213

9. Wan, W., et al.: Exp. Gerontol., 81, 92(2016). EGb761 improves cognitive function and regulates inflammatory responses in the APP/PS1 mouse https://www.ncbi.nlm.nih.gov/pubmed/27220811
10. Tateno, A., et al.: Alzheimers Dement. (Amst)., 9, 51(2017).

Effect of apolipoprotein E phenotype on the association of plasma amyloid β and amyloid positron emission tomography imaging in Japan. https://www.ncbi.nlm.nih.gov/pubmed/28975146

294-62501 Human/Rat β Amyloid(40)ELISA Kit Wako

1. Shimmyo, Y., et al.: J. Neurosci. Res., 86, 2, 368(2008).

Multifunction of myricetin on Aβ: neuroprotection via a conformational change of Aβ and reduction of Aβ via the interference of secretases

https://www.ncbi.nlm.nih.gov/pubmed/17722071

2. Zhang, C., et al.: J. Alzheimers Dis., 22, 2, 683(2010).

Amyloid-β production via cleavage of amyloid-β protein precursor is modulated by cell density. https://www.ncbi.nlm.nih.gov/pubmed/20847415

3. Zhang, C., et al.: J. Biol. Chem., 285, 37, 28472(2010).

 Curcumin decreases amyloid-beta peptide levels by attenuating the maturation of amyloid-beta precursor protein.

https://www.ncbi.nlm.nih.gov/pubmed/20622013

4. Walls, K. C., et al.: J. Biol. Chem., 287, 36, 30317(2012).

Swedish Alzheimer Mutation Induces Mitochondrial Dysfunction Mediated by HSP60 Mislocalization of Amyloid Precursor Protein (APP) and Beta-Amyloid https://www.ncbi.nlm.nih.gov/pubmed/22753410

5. Bryson, J. B., et al.: Hum. Mol. Genet., 21, 17, 3871(2012).

Amyloid precursor protein (APP) contributes to pathology in the SOD1(G93A) mouse model of amyotrophic lateral sclerosis.

https://www.ncbi.nlm.nih.gov/pubmed/22678056

6. Sarajärvi, T., et al.: J. Cell Mol. Med., 16, 11, 2754(2012).

Bepridil decreases A β and calcium levels in the thalamus after middle cerebral artery occlusion in rats

https://www.ncbi.nlm.nih.gov/pubmed/22805236

7. Vepsäläinen, S., et al.: J. Nutr. Biochem., 24, 1, 360(2013).

Anthocyanin-enriched bilberry and blackcurrant extracts modulate amyloid precursor protein processing and alleviate behavioral abnormalities in the APP/PS1 mouse model of Alzheimer's disease

https://www.ncbi.nlm.nih.gov/pubmed/22995388

8. Teich, A. F., et al.: PLoS One., 8, 2, e55647(2013).

A Reliable Way to Detect Endogenous Murine β-Amyloid https://www.ncbi.nlm.nih.gov/pubmed/23383341

9. Dolev, I., et al.: Nat. Neurosci., 16, 5, 587(2013). Spike bursts increase amyloid-β 40/42 ratio by inducing a presenilin-1 conformational change. https://www.ncbi.nlm.nih.gov/pubmed/23563578
10. Ramos-Rodriguez, J. J., et al.: PLoS One, 8, 11, e79947(2013).

Specific serotonergic denervation affects tau pathology and cognition without altering senile plaques deposition in APP/PS1 mice

https://www.ncbi.nlm.nih.gov/pubmed/24278223

11. Kitaoka, K., et al.: Neuropharmacology, 72, 58(2013).

The retinoic acid receptor agonist Am80 increases hippocampal ADAM10 in aged SAMP8 mice https://www.ncbi.nlm.nih.gov/pubmed/23624141

12. Wang, W., et al.: FASEB J., 28, 2, 849(2014).

Amyloid precursor protein α- and β-cleaved ectodomains exert opposing control of cholesterol homeostasis via SREBP2.

 https://www.ncbi.nlm.nih.gov/pubmed/24249638

13. Kanatsu, K., et al.: Nat. Commun., 5, 3386(2014).

Decreased CALM expression reduces Aβ42 to total Aβ ratio through clathrin-mediated endocytosis of γ-secretase

https://www.ncbi.nlm.nih.gov/pubmed/24577224

14. Ramos-Rodriguez, J. J., et al.: Psychoneuroendocrinology, 48, 123(2014).

Prediabetes-induced vascular alterations exacerbate central pathology in APPswe/PS1dE9 mice. https://www.ncbi.nlm.nih.gov/pubmed/24998414

15. Lipsanen, A., et al.: Neurosci. Lett., 580, 173(2014).

KB-R7943, an inhibitor of the reverse Na+/Ca2+ exchanger, does not modify secondary pathology in the thalamus following focal cerebral stroke in rats https://www.ncbi.nlm.nih.gov/pubmed/25123443

16. Rudnitskaya, E. A., et al.: J. Alzheimers Dis., 47, 1, 103(2015)

Melatonin attenuates memory impairment, amyloid-β accumulation, and neurodegeneration in a rat model of sporadic Alzheimer's disease

https://www.ncbi.nlm.nih.gov/pubmed/26402759

17. Tapia-Rojas, C., et al.: Mol. Neurodegener., 10, 62(2015).

Is L-methionine a trigger factor for Alzheimer’s-like neurodegeneration?: Changes in Aβ oligomers, tau phosphorylation, synaptic proteins, Wnt signaling and behavioral impairment in wild-type mice

 https://www.ncbi.nlm.nih.gov/pubmed/26590557

18. Kim, Y. H., et al.: Nat. Protoc., 10, 7, 985(2015).

A 3D human neural cell culture system for modeling Alzheimer's disease. https://www.ncbi.nlm.nih.gov/pubmed/26068894

19. Sarajärvi, T., et al.: J. Alzheimers Dis., 48, 2, 507(2015).

 Genetic variation in δ-opioid receptor associates with increased β-and γ-secretase activity in the late stages of Alzheimer's disease

https://www.ncbi.nlm.nih.gov/pubmed/26402014

20. Leal, N. S., et al.: J. Cell Mol. Med., 20, 9, 1686(2016).

 Mitofusin-2 knockdown increases ER–mitochondria contact and decreases amyloid β‐ peptide production

 https://www.ncbi.nlm.nih.gov/pubmed/27203684

21. Kanatsu, K., et al.: Hum. Mol. Genet., 25, 18, 3988(2016). Partial loss of CALM function reduces Aβ42 production and amyloid deposition in vivo https://www.ncbi.nlm.nih.gov/pubmed/27466196
22. Yamaguchi, T., et al.: Sci. Rep., 6, 34505(2016).

Expression of B4GALNT1, an essential glycosyltransferase for the synthesis of complex gangliosides, suppresses BACE1 degradation and modulates APP processing https://www.ncbi.nlm.nih.gov/pubmed/27687691

23. Sun, M., et al.: Neurobiol. Dis., 93, 1(2016).

The polarity protein Par3 regulates APP trafficking and processing through the endocytic adaptor protein Numb

https://www.ncbi.nlm.nih.gov/pubmed/27072891

24. Ramos-Rodriguez, J. J., et al.: Mol. Neurobiol., 53, 4, 2685(2016).

Increased Spontaneous Central Bleeding and Cognition Impairment in APP/PS1 Mice with Poorly Controlled Diabetes Mellitus.

https://www.ncbi.nlm.nih.gov/pubmed/26156287

25. Stefanova, N. A., et al.: Aging (Albany NY), 8, 11, 2713(2016).

An antioxidant specifically targeting mitochondria delays progression of Alzheimer's disease-like pathology.

https://www.ncbi.nlm.nih.gov/pubmed/27750209

26. Chen, W. T., et al.: PLoS One, 7, 4, e35807(2017).

Amyloid-beta (Aβ) D7H mutation increases oligomeric Aβ42 and alters properties of Aβ-zinc/copper assemblies

https://www.ncbi.nlm.nih.gov/pubmed/22558227

27. Tateno, A., et al.: Alzheimers Dement. (Amst)., 9, 51(2017).

Effect of apolipoprotein E phenotype on the association of plasma amyloid β and amyloid positron emission tomography imaging in Japan. https://www.ncbi.nlm.nih.gov/pubmed/28975146

28. Illouz, T., et al.: J. Neurosci. Methods, 291, 28(2017).

A protocol for quantitative analysis of murine and human amyloid-β1-40 and 1-42. https://www.ncbi.nlm.nih.gov/pubmed/28768163

29. Kolosova, N. G., et al.: Curr. Alzheimer Res., 14, 12, 1283(2017).

 Antioxidant SkQ1 Alleviates Signs of Alzheimer's Disease-like Pathology in Old OXYS Rats by Reversing Mitochondrial Deterioration

https://www.ncbi.nlm.nih.gov/pubmed/28637402

30. Infante-Garcia C., et al.: Mol. Neurobiol., 54, 6, 4696(2017).

Long-Term Mangiferin Extract Treatment Improves Central Pathology and Cognitive Deficits in APP/PS1 Mice.

https://www.ncbi.nlm.nih.gov/pubmed/27443159

31. Ramos-Rodriguez, J. J., et al.: Mol. Neurobiol., 54, 5, 3428(2017).

Progressive Neuronal Pathology and Synaptic Loss Induced by Prediabetes and Type 2 Diabetes in a Mouse Model of Alzheimer's Disease.

https://www.ncbi.nlm.nih.gov/pubmed/27177549

32. Cai, T., et al.: J. Neurosci., 37, 50, 12272(2017).

Activation of γ-Secretase Trimming Activity by Topological Changes of Transmembrane Domain 1 of Presenilin 1.

https://www.ncbi.nlm.nih.gov/pubmed/29118109

33. Kidana, K., et al.: EMBO Mol. Med., 10, 3, (2018).

Loss of kallikrein‐related peptidase 7 exacerbates amyloid pathology in Alzheimer's disease model mice

https://www.ncbi.nlm.nih.gov/pubmed/29311134

34. Sasaguri, H., et al.: Nat. Commun., 9, 1, 2892(2018).

Introduction of pathogenic mutations into the mouse Psen1 gene by Base Editor and Target-AID https://www.ncbi.nlm.nih.gov/pubmed/30042426

294-64701 Human/Rat βAmyloid(40)ELISA Kit Wako Ⅱ

1. Kawahara, K., et al.: Biol. Pharm, Bull., 32, 7, 1307(2009).

Oral administration of synthetic retinoid Am80 (Tamibarotene) decreases brain beta-amyloid peptides in APP23 mice.

https://www.ncbi.nlm.nih.gov/pubmed/19571405

2. Silverberg, G. D., et al.: Brain Res., 1317, 286(2010).

Amyloid and Tau accumulate in the brains of aged hydrocephalic rats https://www.ncbi.nlm.nih.gov/pubmed/20045398

3. Silverberg, G. D., et al.: J. Neuropathol. Exp. Neurol., 69, 1, 98(2010).

Amyloid deposition and influx transporter expression at the blood-brain barrier increase in normal aging.

https://www.ncbi.nlm.nih.gov/pubmed/20010299

4. Hashimoto, M., et al,: Acta Neuropathol., 119, 5, 543(2010).

Analysis of microdissected human neurons by a sensitive ELISA reveals a correlation between elevated intracellular concentrations of Aβ42 and Alzheimer’s disease neuropathology https://www.ncbi.nlm.nih.gov/pubmed/20198479

5. Liu, W., et al.: Neurol. Res., 34, 1, 3(2012).

Isoflurane-induced spatial memory impairment by a mechanism independent of amyloid-beta levels and tau protein phosphorylation changes in aged rats https://www.ncbi.nlm.nih.gov/pubmed/22196855

6. Kawahara, K., et al.: Neuroscience, 207, 243(2012).

Intracerebral microinjection of interleukin-4/interleukin-13 reduces β-amyloid accumulation in the ipsilateral side and improves cognitive deficits in young amyloid precursor protein 23 mice https://www.ncbi.nlm.nih.gov/pubmed/22342341

7. Chiu, C., et al.: Fluids Barriers CNS, 9, 1, 3(2012).

Temporal course of cerebrospinal fluid dynamics and amyloid accumulation in the aging rat brain from three to thirty months

 https://www.ncbi.nlm.nih.gov/pubmed/22269091

8. Liu, H., et al.: Neurobiol. Aging, 33, 4, 826, e31(2012)

Regulation of β-amyloid level in the brain of rats with cerebrovascular hypoperfusion. https://www.ncbi.nlm.nih.gov/pubmed/21813211

9. Keilani, S., et al.: J. Neurosci., 32, 15, 5223(2012).

Lysosomal dysfunction in a mouse model of Sandhoff disease leads to accumulation of ganglioside-bound amyloid-β peptide.

https://www.ncbi.nlm.nih.gov/pubmed/22496568

10. Beyer, A. S., et al.: Neurobiol. Aging, 33, 4, 732(2012).

Engulfment adapter PTB domain containing 1 interacts with and affects processing of the amyloid-β precursor protein

 https://www.ncbi.nlm.nih.gov/pubmed/20674096

11. Ehrlich, D., et al.: Neuroscience, 205, 154(2012).

 Effects of long-term moderate ethanol and cholesterol on cognition, cholinergic neurons, inflammation, and vascular impairment in rats. https://www.ncbi.nlm.nih.gov/pubmed/22244974

12. Arnal, N., et al.: Int. J. Alzheimers Dis., 645379(2013).

Effects of Copper and/or Cholesterol Overload on Mitochondrial Function in a Rat Model of Incipient Neurodegeneration.

https://www.ncbi.nlm.nih.gov/pubmed/24363953

13. Ehrlich, D., et al.: Platelets, 24, 1, 26(2013).

Effects of oxidative stress on amyloid precursor protein processing in rat and human platelets https://www.ncbi.nlm.nih.gov/pubmed/22385218

14. Ai, J., et al.: J. Neurosci., 33, 9, 3989(2013).

MicroRNA-195 protects against dementia induced by chronic brain hypoperfusion via its anti-amyloidogenic effect in rats.

 https://www.ncbi.nlm.nih.gov/pubmed/23447608

15. Hilpert, H., et al.: J. Med. Chem., 56, 10, 3980(2013).

β-Secretase (BACE1) inhibitors with high in vivo efficacy suitable for clinical evaluation in Alzheimer's disease.

https://www.ncbi.nlm.nih.gov/pubmed/23590342

16. Shahani, N., et al,: J. Biol. Chem., 289, 9, 5799(2014).

Rheb GTPase regulates β-secretase levels and amyloid β generation. https://www.ncbi.nlm.nih.gov/pubmed/24368770

17. Church, R. M., et al,: Behav. Neurosci., 128, 4, 523(2014).

Amyloid-beta accumulation, neurogenesis, behavior, and the age of rats. https://www.ncbi.nlm.nih.gov/pubmed/24841744

18. Kawahara, K., et al.: J. Alzheimers Dis. 42, 2, 587(2014).

Cooperative therapeutic action of retinoic acid receptor and retinoid x receptor agonists in a mouse model of Alzheimer's disease.

https://www.ncbi.nlm.nih.gov/pubmed/24916544

19. Collins-Praino, L. E., et al.: Acta Neuropathol. Commun., 2, 83(2014).

Soluble amyloid beta levels are elevated in the white matter of Alzheimer’s patients, independent of cortical plaque severity

 https://www.ncbi.nlm.nih.gov/pubmed/25129614

20. Zhang, X., et al.: Proc. Natl. Acad. Sci. USA, 112, 31, 9734(2015).

Near-infrared fluorescence molecular imaging of amyloid beta species and monitoring therapy in animal models of Alzheimer’s disease

https://www.ncbi.nlm.nih.gov/pubmed/26199414

21. Urich, E., et al.: Sci. Rep., 5, 14104(2015).

Cargo Delivery into the Brain by in vivo identified Transport Peptides. https://www.ncbi.nlm.nih.gov/pubmed/26411801

22. Natunen, T., et al.: Neurobiol. Dis., 85, 187(2016).

Relationship between ubiquilin-1 and BACE1 in human Alzheimer's disease and APdE9 transgenic mouse brain and cell-based models https://www.ncbi.nlm.nih.gov/pubmed/26563932

23. Kurkinen, K. M. et al.: J. Cell Sci., 129, 11, 2224(2016).

SEPT8 modulates β-amyloidogenic processing of APP by affecting the sorting and accumulation of BACE1

https://www.ncbi.nlm.nih.gov/pubmed/27084579

24. Chen, Y., et al.: Stroke, 48, 12, 3366(2017).

2-Cl-MGV-1 Ameliorates Apoptosis in the Thalamus and Hippocampus and Cognitive Deficits After Cortical Infarct in Rats.

https://www.ncbi.nlm.nih.gov/pubmed/29146879

25. Ruderisch, N., et al.: EBioMedicine, 24, 76(2017).

Potent and Selective BACE-1 Peptide Inhibitors Lower Brain Aβ Levels Mediated by Brain Shuttle Transport

https://www.ncbi.nlm.nih.gov/pubmed/28923680

26. Pera, M., et al.: EMBO J., 7 36, 22, 3356(2017).

 Increased localization of APP-C99 in mitochondria-associated ER membranes causes mitochondrial dysfunction in Alzheimer disease. https://www.ncbi.nlm.nih.gov/pubmed/29018038

27. Nakamura, T., et al.: Ann. Clin. Transl. Neurol., 5,10, 1184(2018).

 Aging and APOE-e4 are determinative factors of plasma Ab42 levels https://www.ncbi.nlm.nih.gov/pubmed/30349853

28. Kara, E., et al.: J. Biol. Chem., 293, 34, 13247(2018).

A flow cytometry–based in vitro assay reveals that formation of apolipoprotein E (ApoE)–amyloid beta complexes depends on ApoE isoform and cell type https://www.ncbi.nlm.nih.gov/pubmed/29950521

29. Prasad, H., et al.: Proc. Natl. Acad. Sci. USA, 115, 28, E6640(2018).

Amyloid clearance defect in ApoE4 astrocytes is reversed by epigenetic correction of endosomal pH.

 https://www.ncbi.nlm.nih.gov/pubmed/29946028

30. Ahlemeyer, B., et al.: J. Alzheimers Dis., 61, 4, 1425(2018).

Endogenous Murine Amyloid-β Peptide Assembles into Aggregates in the Aged C57BL/6J Mouse Suggesting These Animals as a Model to Study Pathogenesis of Amyloid-β Plaque Formation. https://www.ncbi.nlm.nih.gov/pubmed/29376876

31. Leskelä S., et al.: J. Alzheimers Dis., 62, 1, 269(2018).

Interrelationship between the Levels of C9orf72 and Amyloid-β Protein Precursor and Amyloid-β in Human Cells and Brain Samples.

https://www.ncbi.nlm.nih.gov/pubmed/29439323

32. Kajiwara, Y., et al.: Acta Neuropathol. Commun., 6, 1, 144(2018). GJA1 (connexin43) is a key regulator of Alzheimer's disease pathogenesis. https://www.ncbi.nlm.nih.gov/pubmed/30577786
33. Sarajärvi, T., et al.: Neuropharmacology, 141, 76(2018).

Protein kinase C-activating isophthalate derivatives mitigate Alzheimer's disease-related cellular alterations

https://www.ncbi.nlm.nih.gov/pubmed/30138694

34. György, B., et al.: Mol. Ther. Nucleic Acids, 11, 429(2018).

CRISPR/Cas9 Mediated Disruption of the Swedish APP Allele as a Therapeutic Approach for Early-Onset Alzheimer's Disease.

https://www.ncbi.nlm.nih.gov/pubmed/29858078

35. Kobayashi, Y., et al.: PLoS One. 13, 6, e0198493(2018).

Oral administration of Pantoea agglomerans-derived lipopolysaccharide prevents metabolic dysfunction and Alzheimer's disease-related memory loss in senescence-accelerated prone 8 (SAMP8) mice fed a high-fat diet.

https://www.ncbi.nlm.nih.gov/pubmed/29856882

36. Xu, J., et al.: J. Pineal. Res., e12584(2019).

 Melatonin Alleviates Cognition Impairment by Antagonizing Brain Insulin Resistance in Aged Rats Fed a High-Fat Diet.

 https://www.ncbi.nlm.nih.gov/pubmed/31050371

298-62401 Human β Amyloid(1-42) ELISA Kit Wako

1. Serrano-Pozo A., et al.: Alzheimer Dis. Assoc. Disord., 3, 220(2010).

Effects of Simvastatin on Cholesterol Metabolism and Alzheimer Disease Biomarkers https://www.ncbi.nlm.nih.gov/pubmed/20473136

2. Zhang, C., et al.: J. Alzheimers Dis., 22, 2, 683(2010).

Amyloid-β production via cleavage of amyloid-β protein precursor is modulated by cell density. https://www.ncbi.nlm.nih.gov/pubmed/20847415

3. Head, E., et al.: J. Alzheimers Dis., 23, 3, 399(2011).

 Plasma amyloid-β as a function of age, level of intellectual disability, and presence of dementia in Down syndrome.

https://www.ncbi.nlm.nih.gov/pubmed/21116050

4. Youmans, K. L., et al.: J. Neurosci Methods, 196, 1, 51(2011).

Amyloid-β42 alters apolipoprotein E solubility in brains of mice with five familial AD mutations https://www.ncbi.nlm.nih.gov/pubmed/21219931

5. Walls, K. C., et al.: J. Biol. Chem., 287, 36, 30317(2012).

Swedish Alzheimer Mutation Induces Mitochondrial Dysfunction Mediated by HSP60 Mislocalization of Amyloid Precursor Protein (APP) and Beta-Amyloid https://www.ncbi.nlm.nih.gov/pubmed/22753410

6. Koppel, J., et al.: Mol. Med., 20, 29(2014).

CB2 Receptor Deficiency Increases Amyloid Pathology and Alters Tau Processing in a Transgenic Mouse Model of Alzheimer’s Disease

https://www.ncbi.nlm.nih.gov/pubmed/24722782

7. Waragai M., et al.: J. Alzheimers Dis., 41, 4, 1207(2014).

Utility of SPM8 plus DARTEL (VSRAD) combined with magnetic resonance spectroscopy as adjunct techniques for screening and predicting dementia due to Alzheimer's disease in clinical practice

https://www.ncbi.nlm.nih.gov/pubmed/24787913

8. Stefanova, N. A., et al.: J. Alzheimers Dis., 38, 3, 681(2014).

Alzheimer's disease-like pathology in senescence-accelerated OXYS rats can be partially retarded with mitochondria-targeted antioxidant SkQ1. https://www.ncbi.nlm.nih.gov/pubmed/24047616

9. Katsuda, T., et al.: Methods Mol. Biol., 1212, 171(2015).

Potential Application of Extracellular Vesicles of Human Adipose Tissue-Derived Mesenchymal Stem Cells in Alzheimer’s Disease Therapeutics https://www.ncbi.nlm.nih.gov/pubmed/25085563

10. Waragai, M., et al.: J. Alzheimers Dis., 60, 4, 1411(2017).

Decreased N-Acetyl Aspartate/Myo-Inositol Ratio in the Posterior Cingulate Cortex Shown by Magnetic Resonance Spectroscopy May Be One of the Risk Markers of Preclinical Alzheimer's Disease: A 7-Year Follow-Up Study.

 https://www.ncbi.nlm.nih.gov/pubmed/28968236

11. Brubaker, W. D., et al.: Alzheimers Dement., 12, 1397(2017).

Peripheral complement interactions with amyloid β peptide: Erythrocyte clearance mechanisms https://www.ncbi.nlm.nih.gov/pubmed/28475854

12. Benvegnù, S., et al.: Oncotarget., 8, 52, 89439(2017).

E3 ligase mahogunin (MGRN1) influences amyloid precursor protein maturation and secretion https://www.ncbi.nlm.nih.gov/pubmed/29163761

13. Kanatsu, K., et al.: J. Neurochem., 147, 1, 110(2018).

Retrograde transport of γ-secretase from endosomes to the trans-Golgi network regulates Aβ42 production.

https://www.ncbi.nlm.nih.gov/pubmed/29851073

14. Ohshima, Y., et al.: Heliyon, 4, 1, e00511(2018).

Mutations in the β-amyloid precursor protein in familial Alzheimer's disease increase Aβ oligomer production in cellular models

https://www.ncbi.nlm.nih.gov/pubmed/29560429

15. Ohshima, Y., et al.: J. Toxicol. Sci., 43, 4, 257(2018).

Nicotine and methyl vinyl ketone, major components of cigarette smoke extracts, increase protective amyloid-β peptides in cells harboring amyloid-β precursor protein. https://www.ncbi.nlm.nih.gov/pubmed/29618714

16. Crane, A., et al.: Alzheimers Dement., 2, 243(2018)

Peripheral complement interactions with amyloid β peptide in Alzheimer's disease: 2. Relationship to amyloid β immunotherapy.

https://www.ncbi.nlm.nih.gov/pubmed/28755839

17. Kusakari, S., et al.: J. Neurochem., 144, 2, 218(2018).

Calmodulin-like skin protein protects against spatial learning impairment in a mouse model of Alzheimer disease.

https://www.ncbi.nlm.nih.gov/pubmed/29164613

18. Robinson, A., et al.: J. Mol. Neurosci., 67, 4, 504(2019).

Combination of Insulin with a GLP1 Agonist Is Associated with Better Memory and Normal Expression of Insulin Receptor Pathway Genes in a Mouse Model of Alzheimer's Disease. https://www.ncbi.nlm.nih.gov/pubmed/30635783

19. Neuner, S. M., et al.: Neuron, 101, 3, 399(2019).

Harnessing Genetic Complexity to Enhance Translatability of Alzheimer’s Disease Mouse Models: A Path toward Precision Medicine

https://www.ncbi.nlm.nih.gov/pubmed/30595332

296-64401 Human β Amyloid(1-42) ELISA Kit Wako, High Sensitive

1. Ohta, K., et al.: Autophagy, 3, 345(2010).

Autophagy impairment stimulates PS1 expression and γ-secretase activity https://www.ncbi.nlm.nih.gov/pubmed/20168091

2. Zhang, C., et al.: J. Alzheimers Dis., 22, 2, 683(2010).

 Amyloid-β production via cleavage of amyloid-β protein precursor is modulated by cell density. https://www.ncbi.nlm.nih.gov/pubmed/20847415

3. Richens, J. L., et al.: Int. J. Mol. Epidemiol. Genet., 5, 2, 53(2014).

Practical detection of a definitive biomarker panel for Alzheimer's disease; comparisons between matched plasma and cerebrospinal fluid https://www.ncbi.nlm.nih.gov/pubmed/24959311

4. Xie, Z., et al.: Ann. Clin. Transl. Neurol., 1, 5, 319(2014). Preoperative cerebrospinal fluid β-Amyloid/Tau ratio and postoperative delirium. https://www.ncbi.nlm.nih.gov/pubmed/24860840
5. Yokoyama, H., et al.: BMC Geriatr., 15, 60(2015).

The effect of cognitive-motor dual-task training on cognitive function and plasma amyloid β peptide 42/40 ratio in healthy elderly persons: a randomized controlled trial https://www.ncbi.nlm.nih.gov/pubmed/26018225

6. Oka, S. et al.: Sci. Rep., 6, 37889(2016).

 Human mitochondrial transcriptional factor A breaks the mitochondria-mediated vicious cycle in Alzheimer's disease.

https://www.ncbi.nlm.nih.gov/pubmed/27897204

7. Wan, W., et al.: Exp. Gerontol., 81, 92(2016).

EGb761 improves cognitive function and regulates inflammatory responses in the APP/PS1 mouse

https://www.ncbi.nlm.nih.gov/pubmed/27220811

8. Tateno, A., et al.: Alzheimers Dement. (Amst)., 9, 51(2017).

 Effect of apolipoprotein E phenotype on the association of plasma amyloid β and amyloid positron emission tomography imaging in Japan. https://www.ncbi.nlm.nih.gov/pubmed/28975146

9. Kidana, K., et al.: EMBO Mol. Med., 10, 3, (2018).

Loss of kallikrein‐related peptidase 7 exacerbates amyloid pathology in Alzheimer's disease model mice

https://www.ncbi.nlm.nih.gov/pubmed/29311134

290-62601 Human/Rat β Amyloid(42)ELISA Kit Wako

1. Shimmyo, Y., et al.: J. Neurosci. Res., 86, 2, 368(2008).

Multifunction of myricetin on Aβ: neuroprotection via a conformational change of Aβ and reduction of Aβ via the interference of secretases https://www.ncbi.nlm.nih.gov/pubmed/17722071 .

2. Kawahara, K., et al.: Biol. Pharm. Bull., 32, 7, 1307(2009).

Oral administration of synthetic retinoid Am80 (Tamibarotene) decreases brain beta-amyloid peptides in APP23 mice.

https://www.ncbi.nlm.nih.gov/pubmed/19571405

3. Zhang, C., et al.: J. Biol. Chem., 285, 37, 28472(2010).

Curcumin decreases amyloid-beta peptide levels by attenuating the maturation of amyloid-beta precursor protein.

https://www.ncbi.nlm.nih.gov/pubmed/20622013

4. Zhang, C., et al.: J. Alzheimers Dis., 22, 2, 683(2010).

Amyloid-β production via cleavage of amyloid-β protein precursor is modulated by cell density. https://www.ncbi.nlm.nih.gov/pubmed/20847415

5. Sarajärvi, T., et al.: J. Cell Mol. Med., 16, 11, 2754(2012).

Bepridil decreases A β and calcium levels in the thalamus after middle cerebral artery occlusion in rats

https://www.ncbi.nlm.nih.gov/pubmed/22805236

6. Kawahara, K., et al.: Neuroscience, 207, 243(2012).

 Intracerebral microinjection of interleukin-4/interleukin-13 reduces β-amyloid accumulation in the ipsilateral side and improves cognitive deficits in young amyloid precursor protein 23 mice https://www.ncbi.nlm.nih.gov/pubmed/22342341

7. Beyer, A. S., et al.: Neurobiol. Aging, 33, 4, 732(2012).

Engulfment adapter PTB domain containing 1 interacts with and affects processing of the amyloid-β precursor protein

https://www.ncbi.nlm.nih.gov/pubmed/20674096

8. Vepsäläinen, S., et al.: J. Nutr. Biochem., 24, 1, 360(2013).

 Anthocyanin-enriched bilberry and blackcurrant extracts modulate amyloid precursor protein processing and alleviate behavioral abnormalities in the APP/PS1 mouse model of Alzheimer's disease

https://www.ncbi.nlm.nih.gov/pubmed/22995388

9. Ramos-Rodriguez, J. J., et al.: PLoS One, 8, 11, e79947(2013).

Specific serotonergic denervation affects tau pathology and cognition without altering senile plaques deposition in APP/PS1 mice

 https://www.ncbi.nlm.nih.gov/pubmed/24278223

10. Kitaoka, K., et al.: Neuropharmacology, 72, 58(2013).

 The retinoic acid receptor agonist Am80 increases hippocampal ADAM10 in aged SAMP8 mice https://www.ncbi.nlm.nih.gov/pubmed/23624141

11. Wang, W., et al.: FASEB J., 28, 2, 849(2014).

Amyloid precursor protein α- and β-cleaved ectodomains exert opposing control of cholesterol homeostasis via SREBP2.

https://www.ncbi.nlm.nih.gov/pubmed/24249638

12. Kawahara, K., et al.: J. Alzheimers Dis. 42, 2, 587(2014).

Cooperative therapeutic action of retinoic acid receptor and retinoid x receptor agonists in a mouse model of Alzheimer's disease.

 https://www.ncbi.nlm.nih.gov/pubmed/24916544

13. Laiterä, T., et al.: PLoS One, 9, 4), e93717(2014).

Increased γ-secretase activity in idiopathic normal pressure hydrocephalus patients with β-amyloid pathology.

https://www.ncbi.nlm.nih.gov/pubmed/24699723

14. Lipsanen, A., et al.: Neurosci. Lett., 580, 173(2014).

KB-R7943, an inhibitor of the reverse Na+/Ca2+ exchanger, does not modify secondary pathology in the thalamus following focal cerebral stroke in rats https://www.ncbi.nlm.nih.gov/pubmed/25123443

15. Ramos-Rodriguez, J. J., et al.: Psychoneuroendocrinology, 48, 123(2014).

Prediabetes-induced vascular alterations exacerbate central pathology in APPswe/PS1dE9 mice. https://www.ncbi.nlm.nih.gov/pubmed/24998414

16. Di, Loreto, S., et al.: Exp. Gerontol., 57, 57(2014).

 Regular and moderate exercise initiated in middle age prevents age-related amyloidogenesis and preserves synaptic and neuroprotective signaling in mouse brain cortex. https://www.ncbi.nlm.nih.gov/pubmed/24835196

17. Stefanova, N. A., et al.: J. Alzheimers Dis., 38, 3, 681(2014).

 Alzheimer's disease-like pathology in senescence-accelerated OXYS rats can be partially retarded with mitochondria-targeted antioxidant SkQ1. https://www.ncbi.nlm.nih.gov/pubmed/24047616

18. Kim, Y. H., et al.: Nat. Protoc., 10, 7, 985(2015).

A 3D human neural cell culture system for modeling Alzheimer's disease. https://www.ncbi.nlm.nih.gov/pubmed/26068894

19. Rudnitskaya, E. A., et al.: J. Alzheimers Dis., 47, 1, 103(2015)

Melatonin attenuates memory impairment, amyloid-β accumulation, and neurodegeneration in a rat model of sporadic Alzheimer's disease

https://www.ncbi.nlm.nih.gov/pubmed/26402759

20. Zhang, Y., et al.: Int. J. Radiat. Biol., 91, 1, 28(2015).

Short-term effects of extremely low frequency electromagnetic fields exposure on Alzheimer's disease in rats.

https://www.ncbi.nlm.nih.gov/pubmed/25118893

21. Leal, N. S., et al.: J. Cell Mol. Med., 20, 9, 1686(2016).

Mitofusin-2 knockdown increases ER–mitochondria contact and decreases amyloid β‐ peptide production

https://www.ncbi.nlm.nih.gov/pubmed/27203684

22. Yamaguchi, T., et al.: Sci. Rep., 6, 34505(2016).

 Expression of B4GALNT1, an essential glycosyltransferase for the synthesis of complex gangliosides, suppresses BACE1 degradation and modulates APP processing https://www.ncbi.nlm.nih.gov/pubmed/27687691

23. Ramos-Rodriguez, J. J., et al.: Mol. Neurobiol., 53, 4, 2685(2016).

Increased Spontaneous Central Bleeding and Cognition Impairment in APP/PS1 Mice with Poorly Controlled Diabetes Mellitus.

https://www.ncbi.nlm.nih.gov/pubmed/26156287 .

24. Stefanova, N. A., et al.: Aging (Albany NY), 8, 11, 2713(2016).

An antioxidant specifically targeting mitochondria delays progression of Alzheimer's disease-like pathology.

 https://www.ncbi.nlm.nih.gov/pubmed/27750209

25. Chen, W. T., et al.: PLoS One, 7, 4, e35807(2017).

Amyloid-beta (Aβ) D7H mutation increases oligomeric Aβ42 and alters properties of Aβ-zinc/copper assemblies

https://www.ncbi.nlm.nih.gov/pubmed/22558227

26. Tateno, A., et al.: Alzheimers Dement. (Amst)., 9, 51(2017).

Effect of apolipoprotein E phenotype on the association of plasma amyloid β and amyloid positron emission tomography imaging in Japan. https://www.ncbi.nlm.nih.gov/pubmed/28975146

27. Infante-Garcia C., et al.: Mol. Neurobiol., 54, 6, 4696(2017).

Long-Term Mangiferin Extract Treatment Improves Central Pathology and Cognitive Deficits in APP/PS1 Mice.

https://www.ncbi.nlm.nih.gov/pubmed/27443159

28. Ramos-Rodriguez, J. J., et al.: Mol. Neurobiol., 54, 5, 3428(2017).

Progressive Neuronal Pathology and Synaptic Loss Induced by Prediabetes and Type 2 Diabetes in a Mouse Model of Alzheimer's Disease.

https://www.ncbi.nlm.nih.gov/pubmed/27177549

29. Chen, Y., et al.: Stroke, 48, 12, 3366(2017).

2-Cl-MGV-1 Ameliorates Apoptosis in the Thalamus and Hippocampus and Cognitive Deficits After Cortical Infarct in Rats.

https://www.ncbi.nlm.nih.gov/pubmed/29146879

30. Illouz, T., et al.: J. Neurosci. Methods, 291, 28(2017).

A protocol for quantitative analysis of murine and human amyloid-β1-40 and 1-42. https://www.ncbi.nlm.nih.gov/pubmed/28768163

31. Yu, M., et al.: J. Ethnopharmacol., 198, 167(2017).

Dehydropachymic acid decreases bafilomycin A1 induced β-Amyloid accumulation in PC12 cells https://www.ncbi.nlm.nih.gov/pubmed/28077330

32. Tomita, T., Methods Enzymol., 584, 185(2017).

 Probing the Structure and Function Relationships of Presenilin by Substituted-Cysteine Accessibility Method.

https://www.ncbi.nlm.nih.gov/pubmed/28065263

33. Kolosova, N. G., et al.: Curr. Alzheimer Res., 14, 12, 1283(2017).

Antioxidant SkQ1 Alleviates Signs of Alzheimer's Disease-like Pathology in Old OXYS Rats by Reversing Mitochondrial Deterioration

https://www.ncbi.nlm.nih.gov/pubmed/28637402

34. Benvegnù, S., et al.: Oncotarget., 8, 52, 89439(2017).

E3 ligase mahogunin (MGRN1) influences amyloid precursor protein maturation and secretion https://www.ncbi.nlm.nih.gov/pubmed/29163761

35. Ramos-Rodriguez, J. J., et al.: Mol. Neurobiol., 54, 5, 3428(2017).

Progressive Neuronal Pathology and Synaptic Loss Induced by Prediabetes and Type 2 Diabetes in a Mouse Model of Alzheimer's Disease.

 https://www.ncbi.nlm.nih.gov/pubmed/27177549

36. Kara, E., et al.: J. Biol. Chem., 293, 34, 13247(2018).

 A flow cytometry–based in vitro assay reveals that formation of apolipoprotein E (ApoE)–amyloid beta complexes depends on ApoE isoform and cell type https://www.ncbi.nlm.nih.gov/pubmed/29950521

37. Tyler, C. R., et al.: Toxicol. Sci., 163, 1, 123(2018).

 Aging Exacerbates Neuroinflammatory Outcomes Induced by Acute Ozone Exposure. https://www.ncbi.nlm.nih.gov/pubmed/29385576

38. Lim, P. H., et al.: Behav. Brain Res., 353, 242(2018).

Premature hippocampus-dependent memory decline in middle-aged females of a genetic rat model of depression

https://www.ncbi.nlm.nih.gov/pubmed/29490235

292-64501 Human/Rat β Amyloid(42) ELISA Kit Wako, High Sensitive

1. Kawahara, K., et al.: Biol. Pharm, Bull., 32, 7, 1307(2009).

Oral administration of synthetic retinoid Am80 (Tamibarotene) decreases brain beta-amyloid peptides in APP23 mice.

 https://www.ncbi.nlm.nih.gov/pubmed/19571405

2. Silverberg, G. D., et al.: Brain Res., 1317, 286(2010).

Amyloid and Tau accumulate in the brains of aged hydrocephalic rats https://www.ncbi.nlm.nih.gov/pubmed/20045398

3. Silverberg, G. D., et al.: J. Neuropathol. Exp. Neurol., 69, 1, 98(2010).

Amyloid deposition and influx transporter expression at the blood-brain barrier increase in normal aging.

https://www.ncbi.nlm.nih.gov/pubmed/20010299

4. Hashimoto, M., et al,: Acta Neuropathol., 119, 5, 543(2010).

Analysis of microdissected human neurons by a sensitive ELISA reveals a correlation between elevated intracellular concentrations of Aβ42 and Alzheimer’s disease neuropathology https://www.ncbi.nlm.nih.gov/pubmed/20198479

5. Liu, W., et al.: Neurol. Res., 34, 1, 3(2012).

Isoflurane-induced spatial memory impairment by a mechanism independent of amyloid-beta levels and tau protein phosphorylation changes in aged rats https://www.ncbi.nlm.nih.gov/pubmed/22196855

6. Bryson, J. B., et al.: Hum. Mol. Genet., 21, 17, 3871(2012).

Amyloid precursor protein (APP) contributes to pathology in the SOD1(G93A) mouse model of amyotrophic lateral sclerosis.

 https://www.ncbi.nlm.nih.gov/pubmed/22678056

7. Chiu, C., et al.: Fluids Barriers CNS, 9, 1, 3(2012).

Temporal course of cerebrospinal fluid dynamics and amyloid accumulation in the aging rat brain from three to thirty months

https://www.ncbi.nlm.nih.gov/pubmed/22269091

8. Liu, H., et al.: Neurobiol. Aging, 33, 4, 826, e31(2012)

Regulation of β-amyloid level in the brain of rats with cerebrovascular hypoperfusion. https://www.ncbi.nlm.nih.gov/pubmed/21813211

9. Keilani, S., et al.: J. Neurosci., 32, 15, 5223(2012).

Lysosomal dysfunction in a mouse model of Sandhoff disease leads to accumulation of ganglioside-bound amyloid-β peptide.

https://www.ncbi.nlm.nih.gov/pubmed/22496568

10. Ehrlich, D., et al.: Neuroscience, 205, 154(2012).

Effects of long-term moderate ethanol and cholesterol on cognition, cholinergic neurons, inflammation, and vascular impairment in rats. https://www.ncbi.nlm.nih.gov/pubmed/22244974

11. Kawahara, K., et al.: Neuroscience, 207, 243(2012).

 Intracerebral microinjection of interleukin-4/interleukin-13 reduces β-amyloid accumulation in the ipsilateral side and improves cognitive deficits in young amyloid precursor protein 23 mice https://www.ncbi.nlm.nih.gov/pubmed/22342341

12. Ito, Y., et al.: Mol. Vis., 18, 2647(2018).

 Induction of amyloid-β(1-42) in the retina and optic nerve head of chronic ocular hypertensive monkeys.

 https://www.ncbi.nlm.nih.gov/pubmed/23170058

13. Ehrlich, D., et al.: Platelets, 24, 1, 26(2013).

Effects of oxidative stress on amyloid precursor protein processing in rat and human platelets https://www.ncbi.nlm.nih.gov/pubmed/22385218

14. Ai, J., et al.: J. Neurosci., 33, 9, 3989(2013).

MicroRNA-195 protects against dementia induced by chronic brain hypoperfusion via its anti-amyloidogenic effect in rats.

 https://www.ncbi.nlm.nih.gov/pubmed/23447608

15. Teich, A. F., et al.: PLoS One., 8, 2, e55647(2013).

A Reliable Way to Detect Endogenous Murine β-Amyloid https://www.ncbi.nlm.nih.gov/pubmed/23383341 .

16. Dolev, I., et al.: Nat. Neurosci., 16, 5, 587(2013).

Spike bursts increase amyloid-β 40/42 ratio by inducing a presenilin-1 conformational change. https://www.ncbi.nlm.nih.gov/pubmed/23563578

17. Natunen, T., et al.: PLoS One, 8, 11, e80700(2013).

 Effects of NR1H3 genetic variation on the expression of liver X receptor α and the progression of Alzheimer's disease.

https://www.ncbi.nlm.nih.gov/pubmed/24278306

18. Natunen, T., et al.: J. Alzheimers Dis., 37, 1, 217(2013).

 Elucidation of the BACE1 regulating factor GGA3 in Alzheimer's disease https://www.ncbi.nlm.nih.gov/pubmed/23970038

19. Kanatsu, K., et al.: Nat. Commun., 5, 3386(2014).

Decreased CALM expression reduces Aβ42 to total Aβ ratio through clathrin-mediated endocytosis of γ-secretase

https://www.ncbi.nlm.nih.gov/pubmed/24577224

 20.. Shahani, N., et al,: J. Biol. Chem., 289, 9, 5799(2014).

 Rheb GTPase regulates β-secretase levels and amyloid β generation. https://www.ncbi.nlm.nih.gov/pubmed/24368770

21. Church, R. M., et al,: Behav. Neurosci., 128, 4, 523(2014).

Amyloid-beta accumulation, neurogenesis, behavior, and the age of rats. https://www.ncbi.nlm.nih.gov/pubmed/24841744

22. Collins-Praino, L. E., et al.: Acta Neuropathol. Commun., 2, 83(2014).

Soluble amyloid beta levels are elevated in the white matter of Alzheimer’s patients, independent of cortical plaque severity

https://www.ncbi.nlm.nih.gov/pubmed/25129614

23. Schütt, T., et al.: J. Vet. Intern. Med., 29, 6, 1569(2015).

Cognitive function, progression of age‐related behavioral changes, biomarkers, and survival in dogs more than 8 years old

https://www.ncbi.nlm.nih.gov/pubmed/26463980

24. Schütt, T., et al.: J. Alzheimers Dis., 52, 2, 433(2016).

Dogs with Cognitive Dysfunction as a Spontaneous Model for Early Alzheimer's Disease: A Translational Study of Neuropathological and Inflammatory Markers. https://www.ncbi.nlm.nih.gov/pubmed/27003213

25. Kanatsu, K., et al.: Hum. Mol. Genet., 25, 18, 3988(2016).

Partial loss of CALM function reduces Aβ42 production and amyloid deposition in vivo https://www.ncbi.nlm.nih.gov/pubmed/27466196

26. Natunen, T., et al.: Neurobiol. Dis., 85, 187(2016).

Relationship between ubiquilin-1 and BACE1 in human Alzheimer's disease and APdE9 transgenic mouse brain and cell-based models https://www.ncbi.nlm.nih.gov/pubmed/26563932

27. Kurkinen, K. M. et al.: J. Cell Sci., 129, 11, 2224(2016).

SEPT8 modulates β-amyloidogenic processing of APP by affecting the sorting and accumulation of BACE1

https://www.ncbi.nlm.nih.gov/pubmed/27084579

28. Pera, M., et al.: EMBO J., 7 36, 22, 3356(2017).

Increased localization of APP-C99 in mitochondria-associated ER membranes causes mitochondrial dysfunction in Alzheimer disease. https://www.ncbi.nlm.nih.gov/pubmed/29018038

29. Gowrishankar, S., et al.: J. Cell Biol., 216, 10, 3291(2017).

Impaired JIP3-dependent axonal lysosome transport promotes amyloid plaque pathology. https://www.ncbi.nlm.nih.gov/pubmed/28784610

30. Cai, T., et al.: J. Neurosci., 37, 50, 12272(2017).

Activation of γ-Secretase Trimming Activity by Topological Changes of Transmembrane Domain 1 of Presenilin 1.

https://www.ncbi.nlm.nih.gov/pubmed/29118109

31. Kolisnyk, B., et al.: Cereb. Cortex., 27, 7,3553(2017).

Cholinergic surveillance over hippocampal RNA metabolism and Alzheimer's-like pathology https://www.ncbi.nlm.nih.gov/pubmed/27312991

32. Ahlemeyer, B., et al.: J. Alzheimers Dis., 61, 4, 1425(2018).

Endogenous Murine Amyloid-β Peptide Assembles into Aggregates in the Aged C57BL/6J Mouse Suggesting These Animals as a Model to Study Pathogenesis of Amyloid-β Plaque Formation. https://www.ncbi.nlm.nih.gov/pubmed/29376876 .

33. Leskelä S., et al.: J. Alzheimers Dis., 62, 1, 269(2018).

Interrelationship between the Levels of C9orf72 and Amyloid-β Protein Precursor and Amyloid-β in Human Cells and Brain Samples.

 https://www.ncbi.nlm.nih.gov/pubmed/29439323

34. Kajiwara, Y., et al.: Acta Neuropathol. Commun., 6, 1, 144(2018).

GJA1 (connexin43) is a key regulator of Alzheimer's disease pathogenesis. https://www.ncbi.nlm.nih.gov/pubmed/30577786 .

35. György, B., et al.: Mol. Ther. Nucleic Acids, 11, 429(2018).

CRISPR/Cas9 Mediated Disruption of the Swedish APP Allele as a Therapeutic Approach for Early-Onset Alzheimer's Disease.

https://www.ncbi.nlm.nih.gov/pubmed/29858078

36. Kobayashi, Y., et al.: PLoS One. 13, 6, e0198493(2018).

Oral administration of Pantoea agglomerans-derived lipopolysaccharide prevents metabolic dysfunction and Alzheimer's disease-related memory loss in senescence-accelerated prone 8 (SAMP8) mice fed a high-fat diet.

 https://www.ncbi.nlm.nih.gov/pubmed/29856882

37. Kidana, K., et al.: EMBO Mol. Med., 10, 3, (2018).

 Loss of kallikrein‐related peptidase 7 exacerbates amyloid pathology in Alzheimer's disease model mice

https://www.ncbi.nlm.nih.gov/pubmed/29311134

38. Shin, J. W., et al.: Am. J. Chin. Med., 46, 6, 1203(2018).

 Scutellarin Ameliorates Learning and Memory Deficit via Suppressing -Amyloid Formation and Microglial Activation in Rats with Chronic Cerebral Hypoperfusion https://www.ncbi.nlm.nih.gov/pubmed/30149759

39. Sarajärvi, T., et al.: Neuropharmacology, 141, 76(2018).

 Protein kinase C-activating isophthalate derivatives mitigate Alzheimer's disease-related cellular alterations

https://www.ncbi.nlm.nih.gov/pubmed/30138694

40. 41. Moser, V. A. et al.: J. Neuroinflammation, 15, 1, 306(2018). TLR4 inhibitor TAK-242 attenuates the adverse neural effects of diet-induced obesity. https://www.ncbi.nlm.nih.gov/pubmed/30396359
41. Xu, J., et al.: J. Pineal. Res., e12584(2019).

Melatonin Alleviates Cognition Impairment by Antagonizing Brain Insulin Resistance in Aged Rats Fed a High-Fat Diet.

https://www.ncbi.nlm.nih.gov/pubmed/31050371

43. Hascup, E. R., et al.: J. Neurochem., 148, 2, 219(2019).

Diet-induced insulin resistance elevates hippocampal glutamate as well as VGLUT1 and GFAP expression in AβPP/PS1 mice.

https://www.ncbi.nlm.nih.gov/pubmed/30472734