Back to: Primary antibodies

GRPR Antibody (Center)

PDFPrintEmail
  • Product Code: #MBT9970c
  • Packaging: 50 µl
    • Base price 1100 元
    Sales price 1100 元
    Discount
    Price / kg:
    Ask a question about this product
    MuBioTech
    AP9790c_WB_2
    Description
    Product Information
    Application 
    		WB, IHC-P, FC, E
    Primary Accession P30550
    Other Accession P52500, P21729
    Reactivity Human, Rat, Mouse
    Predicted Mouse, Rat
    Host Rabbit
    Clonality Polyclonal
    Isotype Rabbit IgG
    Calculated MW 43199 Da
    Antigen Region 123-152 aa
    Additional Information
    Gene ID 2925
    Other Names Gastrin-releasing peptide receptor, GRP-R, GRP-preferring bombesin receptor, GRPR
    Target/Specificity This GRPR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 123-152 amino acids from the Central region of human GRPR.
    Dilution WB~~1:1000
    Format Purified polyclonal antibody supplied in PBS with 0.05% (V/V) Proclin 300. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    Storage Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
    Precautions GRPR Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
    Protein Information
    Name GRPR
    Function Receptor for gastrin-releasing peptide (GRP) (PubMed:1655761). Signals via association with G proteins that activate a phosphatidylinositol-calcium second messenger system, resulting in Akt phosphorylation. Contributes to the regulation of food intake. Contributes to the perception of prurient stimuli and transmission of itch signals in the spinal cord that promote scratching behavior, but does not play a role in the perception of pain. Contributes primarily to nonhistaminergic itch sensation. In one study, shown to act in the amygdala as part of an inhibitory network which inhibits memory specifically related to learned fear (By similarity). In another study, shown to contribute to disinhibition of glutamatergic cells in the auditory cortex via signaling on vasoactive intestinal peptide- expressing cells which leads to enhanced auditory fear memories (By similarity). Contributes to the induction of sighing through signaling in the pre-Botzinger complex, a cluster of several thousand neurons in the ventrolateral medulla responsible for inspiration during respiratory activity (By similarity).
    Cellular Location Cell membrane; Multi-pass membrane protein
    Tissue Location Highly expressed in pancreas (PubMed:11245983). Also expressed in stomach, adrenal cortex and brain (PubMed:11245983) In brain, expressed in cells throughout the cortex (PubMed:34610277)

    Reviews

    There are yet no reviews for this product.